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ea0029oc9.6 | Endocrine Tumours & Translation | ICEECE2012

First in vitro study of human gastroenteropancreatic-neuroendocrine tumors: comparative effect of octreotide and pasireotide

Mohamed A. , Blanchard M. , Albertelli M. , Niccoli P. , Monges G. , Garcia S. , Moutardier V. , Delpero J. , Enjalbert A. , Florio T. , Ferone D. , Saveanu A. , Barlier A.

Somatostatin analogs (SSAs) such as octreotide (OCT) are currently effective in controlling most hypersecretion associated symptoms of Gastoenteropancreatic-neuroendocrinetumors (GEP-NETs). The results of the phase IIIb PROMID trial showed that OCT doubled time to progression for patients with metastatic neuroendocrine midgut tumors compared with placebo. SSAs act on different intracellular pathways through different somatostatin receptor (Sst) subtypes. While OCT is mainly an...

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ea0029p1122 | Neuroendocrinology | ICEECE2012

Ten years of gastroenteropancreatic neuroendocrine tumours: evolution of the classification and correlation with follow-up in 50 patients

Albertelli M. , Grillo F. , Giannone A. , Mastracci L. , Annunziata F. , Arvigo M. , Minuto F. , Fiocca R. , Ferone D.

Gastroenteropancreatic (GEP) neuroendocrine tumours (NETs) are rare neoplasms with heterogeneous clinical behavior and potential long-term survival. In the last decade GEPNET nomenclature has been twice reviewed. However, the 2000 WHO classification had poor prognostic power in well differentiated (WD) neoplasms. This led to the introduction of two new important parameters by the European Neuroendocrine Tumors Society (ENETS), grade and stage; the former became part of t...

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Endocrine Abstracts

First in vitro study of human gastroenteropancreatic-neuroendocrine tumors: comparative effect of octreotide and pasireotide

Ten years of gastroenteropancreatic neuroendocrine tumours: evolution of the classification and correlation with follow-up in 50 patients

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